A Case of GIST in the Duodenum with Multiple Metastases to the Liver Successfully Treated with Surgery and Imatinib Mesilate (STI571)

Yoshiaki Maeda, Shigenori Honnma, Masao Kondo, Yuji Sato and Satoru Todo

Department of Gastroenterological and General Surgery, Hokkaidou University School of Medicine

A 48-years-old man admitted for general fatigue and upper left abdominal pain was found in abdominal US and CT to have a tumor in the left upper abdomen and multiple tumors in the liver. Upper endoscopic findings showed an elevated lesion in the third portion of the duodenum, and histopathological findings showed spindle cell proliferation with mitosis positive for c-kit. We diagnosed the tumor as GIST in the duodenum with multiple metastases to the liver. The duodenum and tumors in the liver were resected and the postoperative course was uneventful. Imatinib mesilate (STI571) at a dose of 400 mg/day was administrated as adjuvant therapy, and he has no sign of recurrence in the 12 months since. This case suggests that complete resection and imatinib mesylate administration are effective in treating GIST with metastases.

Key words
GIST, duodenum, STI571

Reprint requests
Yoshiaki Maeda Department of Gastroenterological and General Surgery, Hokkaidou University School of Medicine
Kita 15-jou Nishi 7-chome, Kitaku, Sapporo, 060-8638 JAPAN

Accepted
June 30, 2004

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