A Case Report of Juvenile Transverse Colon Cancer Associated with Selective IgA Deficiency

Masahiro Murakami, Tadashi Ohnishi, Toshiyuki Kano, Yutaka Kimura, Takashi Iwazawa, Takeshi Tono, Yoshiaki Nakano, Hiroshi Yano, Naohiro Tomita* and Takushi Monden

Department of Surgery, NTT West Osaka Hospital
Department of Surgery, Kansai Rosai Hospital*

A 31-year-old-man with selective IgA deficiency admitted for left-lower abdominal pain in February 2003 and diagnosed with transverse colon cancer, underwent partial transdescending colectomy on March 24, 2003. Histological examination showed moderately differentiated adenocarcinoma. Immunohystochemical examination showed that IgA producing plasma cells in the normal mucosa of the colon had decreased extremely, while cells producing IgG or IgM had increased. Diagnosing this as a case of juvenile colon cancer, we then examined microsatellite instability (MSI) and found it to be MSI-positive. Having no family history of colorectal cancer, this case was strongly suggested to be a de novo case of hereditary non-polyposis colorectal cancer (HNPCC) associated with selective IgA deficiency.

Key words
selective IgA deficiency, juvenile colon cancer, HNPCC

Reprint requests
Masahiro Murakami Department of Surgery, NTT West Osaka Hospital
2-6-40 Karasugatsuji, Tennouji-ku, Osaka, 543-8922 JAPAN

Accepted
September 22, 2004

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