Adenocarcinoma Arising In Chronic Anal Fistula More Than 15 Years: Report of Two Cases

Junichiro Hiro, Yasuhiro Inoue, Hideki Watanabe, Minako Kobayashi*, Chikao Miki and Masato Kusunoki

Department of Surgery II, Mie University School of Medicine
Department of Innovative Surgery*

We report 2 cases of carcinoma arising in anal fistula. Case 1: A 62-year-old man undergoing surgery for anal fistula underwent Seton's drainage 4 times to resolve recurrent disease 17 years after primary surgery. He developed a painful perianal tumor with mucinous discharge. A biopsy specimen showed well-differentiated adenocarcinoma. We conducted abdominoperineal resection (APR) and left inguinal lymph node dissection. Case 2: A 49-year-old man with chronic anal fistula and perianal abscess 18 years after primary surgery developed anal stenosis with large bowel obstruction. He underwent sigmoidstomy to relieve bowel obstruction. Biopsy of the anal fistula tract showed mucinous adenocarcinoma, necessitating APR. Despite postoperative chemoradiotherapy, local recurrence developed 5 years postoperatively. He died 6 years and 7 months after APR due to peritoneal carcinomatosis. Active biopsy of anal fistula and routine imaging may detect cancer early enough to improve survival.

Key words
adenocarcinoma, anal fistula

Reprint requests
Junichiro Hiro Department of Surgery II, Mie University School of Medicine
2-174 Edobashi, Tsu, 514-8507 JAPAN

Accepted
September 22, 2004

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