A Resected Case of Primary Lymphoma of the Liver -Review of Twenty-Seven Resected Cases in Japan-

Kazuharu Kai¹⁾⁴⁾, Toru Beppu¹⁾, Yu Imamura¹⁾, Takatoshi Ishiko¹⁾, Katsunori Imai¹⁾, Koichi Doi¹⁾, Ryuichi Karashima¹⁾, Koei Ikeda¹⁾²⁾, Fumihiko Matsuno³⁾ and Hiroshi Egami¹⁾

Department of Gastroenterological Surgery¹⁾, Department of Pathology²⁾ and Department of Hematology³⁾, Faculty of Medical and Pharmaceutical Sciences of Kumamoto University
Kumamoto City Hospital⁴⁾

A 57-year-old woman admitted for right hypochondoralgia had normal laboratory data and tumor markers and was negative for hepatitis virus type B s-antigen and type C antibody. Ultrasonography showed extremely hypoechoic hepatic tumors of 8.3×6.5 cm in diameter at segment 6 and 1.7×1.5 cm at segmen 8. Drip-infusion cholangiography computed tomography showed highly dense straight vasculature in the S8 tumor, considered to be the biliary duct. Needle biopsy specimens showed undifferentiated carcinoma, necessitating extended right hepatectomy. We found no abdominal splenomegaly or lymphadenopathy, and tumors appeared localized in the liver. Microscopic findings of resected specimens showed tumors to be composed of round lymphocyte-like cells. CD20 protein was positive immunohistochemically, leading to a diagnosis of primary non-Hodgkin's hepatic lymphoma type B. To ensure definitive diagnosis, we should first consider primary lymphoma differentially, then conduct immunohistochemical staining with biopsy specimens.

Key words
needle biopsy, primary hepatic lymphoma, immunohistochemical staining

Reprint requests
Kazuharu Kai The Department of Surgery, Kumamoto City Hospital
1-1-60 Kotou, Kumamoto, 862-8505 JAPAN

Accepted
January 26, 2005

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