A Case of Gastrointestinal Stromal Tumor of the Duodenum with Liver Metastase

Shigenori Sugihara, Yutaka Tsuruta, Eiichiro Toyama, Mutsuo Tanaka and Mihoko Setoguchi*

Department of Gastroenterological Surgery and Department of Pathology*, Shimonoseki Welfare Social Hospital

We report a case of gastrointestinal stromal tumor (GIST) of the duodenum with liver metastasis. A 50-year-old woman admitted for appetite loss and abdominal pain was found in upper gastrointestinal endoscopy to have a tumor with ulceration at the 2nd portion of duodenum. Abdominal computed tomography showed a mass 10 cm in diameter involving the duodenum and a low-density mass in the liver, necessitating pylorus-preserving pancreatoduodenectomy and hepatectomy. Histopathologically, the tumor arose from the proper muscle layer of the duodenum, and was positive for c-kit and negative for CD34, S100 protein, and SMA on immunostaining. The tumor was diagnosed as combined malignant GIST.

Key words
gastrointestinal stromal tumor, duodenum, liver metastasis

Reprint requests
Shigenori Sugihara Department of Gastroenterological Surgery, Shimonoseki Welfare Social Hospital
3-3-8 Kamishinchimachi, Shimonoseki, 750-0061 JAPAN

Accepted
March 30, 2005

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