The Factor Influencing Good Prognosis of Gallbladder Cancer -Invading the Subserosal Layer Relationship between the Maximal Horizontal Size of Subserosal Invasion and the Prognosis-

Takashi Hara, Hideaki Kawashima, Masahiro Ishigooka, Motoya Kashiyama, Setsuji Takanashi, Makoto Yoshida and Yoshio Hosokawa

Department of Surgery, Kin-I-Kyo Chuo Hospital

Aim: We clarified whether the maximal horizontal size of subserosal invasion influences prognosis. Materials and Methods: Of 69 patients with gallbladder cancer who underwent surgical resection between 1975 and 2002, 28 had T2 gallbladder cancer (depth of invasion ss, including hinfα and excluding positive binf). We studied the relationship between pathological factors of resected specimens and prognosis. Results: Subjects were 28 patients- 6 men and 22 women aged 45 to 82 years (mean 67.6 years). Five-year postoperative survival of the 28 was 48%. Presence of lymph node metastasis, positive em, and positive bm were significant factors related to poor prognosis. Patients with INF α showed relatively good prognosis, as did those with subserosal invasion less than 10 mm in maximal horizontal size, whose prognosis was significant good. Discussion: Results suggested that the factor showing good prognosis was a maximal horizontal size of less than 10 mm invading the subserosal layer. Preoperative diagnosis of subserosal invasion is reported to be possible to some extent by EUS, so this factor will provide useful preoperative information.

Key words
ss gallbladder cancer, maximal horizontal size invading subserosal layer, prognostic factor

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Takashi Hara Department of Surgery, Kin-I-Kyo Chuo Hospital
2-15-1 10-jo, Fushiko, Higashi-ku, Sapporo, 007-8505 JAPAN

Accepted
April 27, 2005

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