A Case of Splenic Marginal Zone Lymphoma Diagnosed after Splenectomy for ITP

Makiko Tanaka, Hiroyuki Naitoh, Hiroshi Yamamoto, Yasuhisa Tango, Tohru Tani, Mitsuaki Ishida¹⁾, Ryohji Kushima²⁾ and Hidetoshi Okabe¹⁾²⁾

Department of Surgery, Division of Clinical Laboratory Medicine¹⁾ and Division of Diagnostic Pathology²⁾, Shiga University of Medical Science

We report a case of splenic marginal zone lymphoma (SMZL) diagnosed after splenectomy for idiopathic thrombocytopenic purpura (ITP). A 30-year-old woman diagnosed with ITP 5 years earlier and treated with steroids did not have the platelets count increase sufficiently, leading to splenectomy using hand-assisted laparoscopic surgery (HALS). Based on microscopic findings with HE staining and immunohistochemistry staining for CD20 and Ki67, she was diagnosed with SMZL. Platelets counts and PAIgG normalized after splenectomy. These findings suggest that SMZL may have caused ITP.

Key words
splenic marginal zone lymphoma, idiopathic thrombocytopenic purpura, hand-assisted laparoscopic surgery

Reprint requests
Makiko Tanaka Department of Surgery, Shiga University of Medical Science
Setatukinowa-cho Otsu, 520-2192 JAPAN

Accepted
June 22, 2005

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