A Case of Multiple Corectal Cancer with X-Linked Hypogammaglobulinemia

Keiko Nishiguchi and Hirohiko Onoyama

Department of Surgery, Saiseikai Nakatsu Hospital, Osaka

We report on a 31-year-old man with X-linked hypogammagloblinemia who developed multiple colorectal cancer. An immunodeficiency had been diagnosed in the patient since four years of age. On family history, his three uncle had died in infancy due to infection, and one brother was also diagnosed as hypogammagloblinemia. He had visited a fanily doctor due to abdominal pain and anal bleeding. Three cancers of the rectosigmoid region were detected by barium enema and low anterior resection was performed, and resected specimen revealed tumors lesions, including 3 cancers and 3 adenomas. Immnogurobulin was supplied intra venously after operation. However, β-D glucan was elevated to 114.2 pg/ml, post operative course was uneventful. Considering family history and Methyl pyronne staining of the specimen, the hypogammagloblinemia of the patient was considered as X-linked disease. We reported a rare case of colorectal cancer combined with hypogammagloblinemia.

Key words
congenital immunodeficiency, multipls colorectal cancer, X-linked hypogammaglobulinemia

Reprint requests
Hirohiko Onoyama Department of Surgery, Saiseikai Nakatsu Hospital
2-10-39 Shibata, Kita-ku, Osaka, 530-0012 JAPAN

Accepted
October 19, 2005

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