A Clinicopathological Study of Our 10 Cases with Primary Carcinoma of the Duodenum

Shunsuke Onoe, Takehito Katoh, Yoshihisa Shibata, Masaomi Suzuki, Shigemi Onoue, Keiichi Nagasawa, Motoi Yoshihara, Yoshiro Taguchi, Harumitu Ando and Hiroaki Usui

Department of Surgery, Toyohashi Municipal Hospital

Primary carcinoma of the duodenum is an uncommon disease. We clinicopathologically examined 10 cases undergoing resection of primary duodenal cancer in our hospital. The mean age of the patients was 73 years, and there were 8 males and 2 females. All the patients visited the hospital complaining of some symptoms, the most common of which was vomiting, and were diagnosed as having advanced carcinoma. Most of the tumors were situated in the bulb and the second portion of the duodenum. Pancreatoduodenectomy was performed in 9 cases. Macroscopically, 5 tumors were ulcerative type and microscopically, 5 tumors were moderately differentiated adenocarcinomas. The 5-year-survival rate was 58%, which was better than that of the other periampullary carcinomas. Among 73 reported cases in the past 10 years in Japan, statistical analysis suggested that the depth of invasion, metastasis to lymph nodes and invasion of the pancreas were significant prognostic indicators. Curative resection for carcinoma of the duodenum might contribute to long-term survival, judging from our results that two patients with tumors showing nodal involvemet and pancreas invasion survived for 5 years.

Key words
primary carcinoma of the duodenum, prognostic factor, periampullary carcinoma

Reprint requests
Shunsuke Onoe Toyohashi Municipal Hospital
50 Hakkennishi, Aotake-cho, Toyohashi, 441-8570 JAPAN

Accepted
December 16, 2005

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