Splenic Inflammatory Myofibroblastic Tumor with Amyloid Deposition -A Case Report-

Hidetaka Yamanaka, Kaname Ono, Tatsuro Satoh, Yuuji Iida and Satoshi Kamiya

Department of Surgery, Inuyama Chuo Hospital

Inflammatory myofibroblastic tumor (IMT) is defined as a mass lesion consisting of proliferating of myofibroblasts and inflammatory cell infiltration, discovered for study of pulmonary inflammatory pseudotumor, and it occurs at many sites in the body, and it discussed essence as inflammation or neoplasm. We repot a case of splenic IMT. A 32-year-old woman was admitted to our hospital for abdominal pain. Blood examination showed leukocytosis and anemia, and she operated splenectomy as diagnosed splenic tumor by abdominal US and CT and MRI and angiography. Histological examination of the resected specimen revealed splenic IMT with amyloid deposition. After operation, leukocytosis and anemia were improved and no reccurence detected for 22 months. This is the second case of splenic IMT reported in Japan and the first case of IMT with amyloid deposition reported all over the world. Negative for ALK-1 and positive for deposition of AA-type amyloid, our patient's tumor was suggesting an inflammatory lesion.

Key words
splenic inflammatory myofibroblastic tumor, AA-type amyloid

Reprint requests
Hidetaka Yamanaka Department of Surgery, Inuyama Chuo Hospital
6 Futagozuka, Goroumaru, Inuyama, 484-8511 JAPAN

Accepted
March 22, 2006

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