A Case of KIT-negative Gastrointestinal Stromal Tumor of the Small Intestine Respond to Imatinib after Surgical Intervention

Tomoharu Sugie, Yumi Matsushima*, Toshihiro Nagai and Kazuhisa Ohgaki

Department of Surgery and Department of Medicine*, Kyoto Police Hospital

A 70-year-old male was admitted for gastrointestinal bleeding. Endoscopic examinations failed to detect the site of the bleeding, and a CT scan disclosed a single liver mass and several intra-abdominal tumors. The preoperative diagnosis was metastatic GIST with intestinal bleeding, and the segment of small intestine involved 70 cm distal to the ligament of Treitz and some peritoneal disseminated masses were resected. The resected tumors were microscopically examined and classified as CD34⁺, c-kit^-, SMA^-, S100^- GISTs. Treatment with 400 mg of imatinib started 24 days later and positron emission tomography (PET) 7 days later showed a marked decrease in abdominal uptake compared with PET before treatment. Adverse effects were minimal and the patient's disease has been stable during fifteen months since imatinib was started.

Key words
gastrointestinal stromal tumor, small intestine, imatinib

Reprint requests
Tomoharu Sugie Department of Surgery, Kyoto Police Hospital
14 Koyamakitakamifusa-cho, Kita-ku, Kyoto, 603-8142 JAPAN

Accepted
March 22, 2006

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