A Case of Primary Squamous Cell Carcinoma of the Stomach: A Review of 51 Cases in Japanese Literature

Hidenobu Okino, Yuji Shinagawa, Motomasa Hiroyoshi, Kazuo Shimada, Jiro Watanabe* and Shigeaki Takeda

Department of Surgery and Clinical Research and Department of Pathology*,
National Hospital Organization, Kokura Hospital

The case of a 55-year-old man with a primary squamous cell carcinoma (SCC) of the stomach that was cured surgically is reported. The clinicopathological features of 51 cases of primary SCC of the stomach reported in Japan were reviewed and compared with the data for the common type of gastric carcinoma. The male-to-female ratio (3.3:1) and patient age (64.5±12.6 yo) were higher than those of the common type of gastric carcinoma. In 51 cases, 24 cases (47%) showed that the lesion was located in the upper third of the stomach and only 2 cases (4%) were early carcinoma, both of which indicated that SCC of the stomach had characteristics distinct from those of the common type of gastric carcinoma. In 40 cases (78%) there was invasion beyond the subserosal layer, and in 35 cases (69%) there was local and/or distant metastasis. The majority of cases (70%) had already progressed to stage III-IV at the time of operation, which showed a very poor prognosis (5-year survival rate: 35.6%). The pathogenesis of this disease has been argued by many authors but remains obscure. Genetical studies will be necessary to clarify the pathogenesis of this rare tumor.

Key words
gastric carcinoma, stomach, squamous cell carcinoma

Reprint requests
Hidenobu Okino Department of Surgery and Clinical Research, National Hospital Organization, Kokura Hospital
10-1 Harugaoka, Kokuraminami-ku, Kitakyushu, 802-8533 JAPAN

Accepted
April 26, 2006

To read the PDF file you will need Abobe Reader installed on your computer.