A Case of Advanced Gallbladder Cancer derived from the Rokitansky-Aschoff Sinus

Masaya Hattori, Takao Kunou, Syunpei Yokoi, Satomi Saeki, Yoshito Okada, Hiroaki Shibahara, Tetsuya Abe, Kenichirou Satou, Takeo Kawahara and Seijun Hayakawa*

Department of Surgery and Department of Pathology*, Anjo Kosei Hospital

We report a case of advanced gallbladder cancer derived from the Rokitansky-Aschoff sinus. A 50-year-old man admitted for gallbladder wall thickening detected by ultrasonography had his condition confirmed in computed tomography, ERCP, MRCP, and EUS, No apparent gallbladder cancer was found. Under a diagnosis of adenomyomatosis with chronic cholecystitis, we conducted laparoscopic cholecystectomy. Macroscopic findings for the resected specimen showed wall thickening, but no malignant lesion in the mucosal layer. Histopathological examination of the resected specimen showed well-differentiated adenocarcinoma in the Rokitansky-Aschoff sinus accompanied by subserosal and perineural invasion. Histopathological examination of total segmentation of the resected specimen showed no malignant lesion in the mucosal layer of the gallbladder. We conducted additional surgery, including partial hepatectomy, regional lymphadenectomy, and extra bile duct resection. We found no malignant lesion. Gallbladder cancer derived from the Rokitansky-Aschoff sinus is rare. In most reported cases, gallbladder cancer derived from the Rokitansky-Aschoff sinus is noninvasive carcinoma.

Key words
advnced gallbladder cancer, Rokitansky-Aschoff sinus

Reprint requests
Masaya Hattori Department of Surgery, Anjo Kosei Hospital
28 Higashihirokute, Anjo-cho, Anjo, 446-8602 JAPAN

Accepted
April 26, 2006

To read the PDF file you will need Abobe Reader installed on your computer.