A Case of Endocrine Tumor of Pancreas with Multiple Liver Metastases Successfully Treated with Hepatic Arterial Chemotherapy

Shinichi Sugiyama, Toru Beppu, Takatoshi Ishiko, Masashi Takahashi, Yoshikatsu Koga, Toshiro Masuda, Kazutoshi Okabe¹⁾, Koei Ikeda²⁾, Masahiko Hirota and Hideo Baba

Department of Gastroenterological Surgery, Faculty of Medical and Pharmaceutieal Sciences,Kumamoto University
Department of Surgery, NTT West Japan Kyusyu Hospital¹⁾
Department of Surgical Pathology, Kumamoto University School of Medicine²⁾

We report a patient with multiple liver metastases from pancreatic endocrine tumors who was successfully treated by hepatic arterial chemotherapy. A patient was a 33-year old woman. Primary pancreatic tumor was not found initially which was diagnosed as endocrine tumor by needle biopsy of liver tumors. She was treated with transcatheter arterial chemoembolization (TACE) using CDDP/lipiodol or MMC/degradable starch microspheres at first. She was scheduled to undergo hepatic arterial infusion (HAI), but was treated with oral administration of UFT-E because of obstruction of the brachial artery. Liver metastases of patient responded dramatically to treatment and rapidly shrank. But ovarian metastasis was detected 4 months after initial therapy and oophorectomy was done. Since abdominal lymph node, brain, and bone metastasis, peritoneal dissemination and regrowth of liver metastasis were observed, systemic chemotherapy using paclitaxel with a high inhibition index based on in vitro chemosensivity test was done but the disease progressed gradually, and she died 15 months after initial therapy.

Key words
endocrine tumor of the pancreas, liver metastasis, hepatic arterial chemotherapy

Reprint requests
Shinichi Sugiyama Department of Surgery, Japanese Red Cross Kumamoto Hospital
2-1-1 Nagamineminami, Kumamoto, 861-8520 JAPAN

Accepted
May 31, 2006

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