A Resected Case of Duodenal Neuroendocrine Carcinoma

Shigeru Fujisaki¹⁾³⁾, Motoi Takashina¹⁾, Ryouichi Tomita²⁾, Tadatoshi Takayama³⁾ and Toshimiti Oinuma⁴⁾

Department of Surgery, Fujisaki Hospital¹⁾
Department of Surgery, Nippon Dental University School of Dentist at Tokyo²⁾
Department of Digestive Surgery³⁾ and Department of Pathology⁴⁾, Nihon University School of Medicine

We report a case of neuroendocrine carcinoma of the duodenum. A 76-year-old man came to our hospital, complaining of dizziness. Laboratory data showed anemia. Abdominal CT revealed a 3-cm mass on the ventral side of the pancreatic head, and duodenoscopy showed a 4-cm elevated lesion with ulceration in the first part of the duodenum. Biopsy showed a malignant epithelial neoplasm of the duodenum. Partial duodenectomy and excision of a metastatic lymph node was performed for a preoperative diagnosis of a duodenal cancer with a metastatic lymph node, and followed by adjuvant chemotherapy with tegafur. Immunohistochemical analysis showed positive staining for chromogranin and synaptophysin. The definitive diagnosis was neuroendocrine carcinoma of the duodenum. The patient has survived for more than 36 months after surgery with no signs of recurrence.

Key words
neuroendocrine carcinoma, duodenum

Reprint requests
Shigeru Fujisaki Department of Surgery, Fujisaki Hospital
1-25-11 Minamisuna, Koto-ku, 136-0076 JAPAN

Accepted
September 27, 2006

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