A Case of the Gastric Carcinoma with Extragastric Growth and Differentiation to Yolk Sac Tumor

Toru Yoshida*, Naohiro Shimakage, Akio Kusama, Katsuyuki Uchida, Naotaka Okamura, Kenzou Tajima and Kazuhiro Tsukada*

Department of Surgery, Nagaoka Red-Cross Hospital
Second Department of Surgery, University of Toyama*

A 43-year-old woman presented with anemia and a large tumor in the lower abdomen, and the tumor was diagnosed as gastric carcinoma (type 2) with extra-gastric growth by CT, MRI, and UGI endoscopy. The serum AFP level was extremely high (42,735 ng/ml). Distal gastrectomy and resection of the transverse colon was performed. The large tumor (14×12×12 cm) arose from the antrum of the stomach, and it involved the mesocolon of the transverse colon. The histological diagnosis showed that the tumor consisted of two components. One was a moderately differentiated adenocarcinoma of a Type 2 cancer, and the other was a yolk sac tumor of an extragastric growth component. Immunohistochemically, AFP was positive in almost all of the yolk sac tumor cells and in a few of the adenocarcinoma cells. This finding suggests that the yolk sac tumor arose from the component of the adenocarcinoma that was AFP-positive.

Key words
yolk sac tumor, gastric carcinoma, AFP

Reprint requests
Toru Yoshida Second Department of Surgery, University of Toyama
2630 Sugitani, Toyama, 930-0194 JAPAN

Accepted
November 22, 2006

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