A Case Report of Adeno-Squamous Cell Carcinoma, in which Adenocarcinoma Component was Eliminated after Pre-Operative Chemotherapy

Hidekazu Takahashi, Shin Mizutani, Toshirou Nishida¹⁾, Tsukasa Ooyama, Fumihiro Uchikosi, Katsuhide Yoshidome, Masayuki Tori, Shigeyuki Ueshima, Masaaki Nakahara and Masahiko Tsujimoto²⁾

Department of Surgery, Osaka Police Hospital
Department of Surgery, Osaka University Graduated School of Medicine¹⁾
Department of Pathology, Osaka Police Hospital²⁾

A 74-year-old man admitted our hospital for general fatigue and anemia was found in endoscopic examination to have type 2 cancer in the gastric body. While most biopsy specimens were diagnosed as adenocarcinoma, some were squamous cell carcinoma. Computed tomography (CT) showed direct invasion of the tumor to the pancreas and lymph node metastases. We conducted 3 courses of S-1/CDDP to downstage the tumor before surgery. Pre-operative chemotherapy was evaluated NC in follow-up CT. We conducted total gastrectomy with distal pancreatectomy and splenectomy. Post operative pathological examination showed that the tumor remaining consisted of squamous cell carcinoma free of any adenocarcinoma component. The fact that chemotherapy eliminated the adenocarcinoma component but not the squamous compornent suggests that sensitivity to combined S-1 and CDDP chemotherapy may differ between adenocarcinoma and squamous cell carcinoma.

Key words
gastric adenosquamous carcinoma, neoadjuvant chemotherapy

Reprint requests
Hidekazu Takahashi Department of Surgery, Osaka Police Hospital
10-31 Kitayama, Tennouji-ku, Osaka, 543-0035 JAPAN

Accepted
January 31, 2007

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