A Resected Case of Splenic T-cell Malignant Lymphoma

Ken Dabanaka, Michiya Kobayashi, Tsutomu Namikawa, Ryuji Yoshioka, Ken Okamoto, Takehiro Okabayashi, Hiromichi Maeda, Toyoichi Akimori, Tateki Sugimoto and Kazuhiro Hanazaki

Department of Surgery, Kochi Medical School

Methotrexate-lymphoproliferative disorder in rheumatoid arthritis patients treated with Methotrexate. We reported a case of splenic T-cell malignant lymphoma in a patient with rheumatoid arthritis treated with Methotrexate. A 73-year-old woman treated with Methotrexate for 10 years showed high levels of CA125 334.8 U/ml and IL-2 receptor antibody of 4,390 U/ml. Abdominal contrast-enhanced computed tomography and magnetic resonance imaging showed mass lesions in the spleen. FDG-PET showed splenic FDG accumulation. Based on a diagnosis of malignant splenic lymphoma, we conducted manually assisted laparoscopic splenectomy.

Key words
methotrexate-associated lymphoproliferative disorder, T-cell malignant lymphoma, hand-assited laparoscopic splenectomy

Reprint requests
Ken Dabanaka Department of Surgery, Kochi Medical School
Kohasu-Okocho, Nankoku, 783-8505 JAPAN

Accepted
April 25, 2007

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