Gender Differences in the Prognostic Factor of Severe Acute Pancreatitis

Takeo Yasuda, Takashi Ueda, Yoshifumi Takeyama*, Makoto Shinseki, Hidehiro Sawa, Takahiro Nakajima, Ippei Matsumoto, Tetsuo Ajiki, Yonson Ku and Yoshikazu Kuroda

Department of Surgery, Kobe University Graduate School of Medical Sciences
Department of Surgery, Kinki University School of Medicine*

Purpose: Gender differences are assumed to exist in the biological response to medical insult and clinical outcome. We clarified gender differences in prognostic factors of severe acute pancreatitis (SAP). Methods: We compared backgrounds between men and women with SAP, then divided 146 patients with SAP into survivor (80 men and 24 women) and nonsurvivor (28 men and 14 women) groups and surveyed significantly different prognostic factors in laboratory data on admission. Results: The mean onset age in women was significantly higher than that in men. The most frequent etiology of SAP was alcohol in men, and gall stones in women. BE, BUN, Cr, Ca, BS, LDH, AST, PT, T-Bil, and PaO₂ showed significant differences in men. We found significant differences in lymphocyte counts, BUN and Cr in women. BE on admission was significantly lower in nonsurviving men (-7.1±1.2 mEq/L) than in surviving men (-0.8±0.8 mEq/L). Lymphocyte count on admission was significantly lower in nonsurviving women (539±74/mm³) than in surviving women (1,101±211/mm³). Conclusions: Prognostic factors on admission appear to differ by gender in patients with SAP, i.e., BUN and Cr show no gender difference, BE differs in men, and lymphocyte counts differ in women.

Key words
severe acute pancreatitis, prognostic factor, gender difference

Reprint requests
Takeo Yasuda Department of Surgery, Kinki University School of Medicine
377-2 Onohigashi, Osaka-sayama, 589-8511 JAPAN

Accepted
February 20, 2008

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