Granular Cell Tumor of the Stomach: Report of Two Cases

Koichiro Sano, Ichiro Niina, Hideki Hidaka, Naoki Maehara, Koki Nagaike, Shuichiro Uchiyama, Masayuki Hotokezaka, Kousuke Marutsuka¹⁾, Yutaka Akiyama²⁾ and Kazuo Chijiiwa

Department of Surgical Oncology and Regulation of Organ Function, Pathology Devision University of Miyazaki Hospital¹⁾ and Department of Pathology Section of Oncopathology and Regenerative Biology²⁾, Miyazaki University School of Medicine

We report two resected cases of gastric granular cell tumors. Case 1: A 40-year-old man admitted after gastroscopy showed a submucosal tumor 1.5 cm in diameter with a molar-like appearance at the greater curvature of the gastric fundus. Biopsy showed a granular cell tumor necessitating laparoscopic partial resection of the stomach. Case 2: A 42-year-old woman admitted for epigastralgia was found in gastroscopy to have a submucosal tumor 1.5 cm in diameter on the lesser curvature of the lower stomach. Histological diagnosis was not accurate and a carcinoid tumor could not be ruled out, so we partially resected the stomach. Both resected specimens were microscopically located in the submucosal layer. Tumor cells were arranged in small clusters with long, abundant granular eosinophilic cytoplasm strongly positive for PAS and S-100 protein. Both cases were pathologically diagnosed as granular cell tumors. Such gastric tumors are rare, with only 32 cases reported in Japan.

Key words
granular cell tumor, stomach

Reprint requests
Kazuo Chijiiwa Department of Surgical Oncology and Regulation of Organ Function, Miyazaki University School of Medicine
5200 Kihara, Kiyotake, Miyazaki, 889-1692 JAPAN

Accepted
May 21, 2008

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