A Resected Case of Adenosquamous Cell Carcinoma of the Pancreas with Colonic Obstruction

Jun Kanamori, Michio Kanai, Ryuzou Yamaguchi, Katura Hamaguchi, Muneyasu Kiriyama and Fumiya Satou

Department of Surgery, Kasugai Municipal Hospital

We report a rare case of adenosquamous cell carcinoma of the pancreas with colonic obstruction together with a review of the literature. A 77-year-old woman referred for periumbilical pain and diagnosed with colonic obstruction in January 2007 was found in enema studies to have total colonic obstruction of the splenic flexture necessitating emergency loop colostomy of the transverse colon. Microscopic colonoscopic biopsy findings showed adenocarcinoma, positive for cytokeratin (CK) 7 and negative for CK20 in immunohistochemistry-a pattern not typical of colonic cancer. Further examinations led to a diagnosis of pancreatic-tail cancer with invasion of the descending colon, necessitating distal pancreatectomy with splenectomy, left colectomy, left nephrectomy, and partial gastric and diaphragmatic resection in February 2007. 13 months after surgery, she is doing well without sign of recurrence. Histopathological diagnosis was adenosquamous cell carcinoma of the pancreas that had infiltrated the splenic capsule, the hilum of left kidney and the descending colon.

Key words
adenosquamous cell carcinoma of the pancreas, colonic obstruction

Reprint requests
Jun Kanamori Department of Surgery, Kasugai Municipal Hospital
1-1-1 Takaki-cho, Kasugai, 486-8510 JAPAN

Accepted
April 23, 2008

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