Perforated Colon Ulcer induced by Nonsteroidal Anti-Inflammatory Drugs

Chika Sakimura, Akemi Iwamoto, Nariyuki Yamane, Osamu Kimura, Ryuichi Hamazoe and Yoko Murata*

Department of Surgery, National Hospital Organization Yonago Medical Center
Department of Surgery, Yonago Hakuai Hospital*

We report the rare case of a 59-year-old man suffering a perforated colon ulcer induced by nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac sodium tablets admitted at 75 mg/day were administrated for lumbago due to spinal canal stenosis. After six days, the man experienced anorexia, abdominal fullness, and upper right abdominal pain. Physical examination showed signs of peritoneal irritation. Based on a diagnosis of diffuse suppurative peritonitis, we conducted emergency transverse colectomy, finding two perforated ulcer sites and one non-perforated ulcer at the resected transverse colon. Histological examination showed non-atypical cells in the mucosal tissue around the ulcers. It is thus important to bear colon disease mind when NSAIDs are administered as a painkiller.

Key words
NSAIDs, colon ulcer, perforation

Reprint requests
Ryuichi Hamazoe Department of Surgery, National Hospital Organization Yonago Medical Center
4-17-1 Kuzumo, Yonago, 683-8518 JAPAN

Accepted
May 21, 2008

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