A Resected Case of Hepatosplenic Malignant Lymphoma with Hepatitis B Virus Infection

Ryosuke Shibata, Shunji Kawamoto, Kazuo Inada, Takayuki Kanemaru, Nobuhiro Kodama*, Kazutaka Hirota* and Taruhisa Yoshida**

Department of Surgery, Department of Internal Medicine* and Department of Pathology**, Fukuoka Tokusyuukai Hospital

We report to our knowledge the first case of resected hepatosplenic malignant lymphoma. A 55-year-old Jehovah's Witness woman underwent abdominal CT showing solid masses in the liver and spleen. Superficial lymph nodes were not palpated. Laboratory data showed LDH of 711 IU/l, positive HBsAg, and IL-2R of 748 U/ml. A liver biopsy showed diffuse multiplication of large B cell type lymphocytes. A diagnosis of malignant lymphoma localized in the liver and spleen was made by bone marrow tap, head MRI, and FDG-PET. Because of impending tumor rupture, we conducted lateral segmentectomy of the liver followed by splenectomy. THP-COP therapy was conducted postoperatively in 3 courses. She has had no recurrence in 3 years.

Key words
malignant lymphoma, liver and spleen, Hepatitis B

Reprint requests
Ryosuke Shibata Department of Surgery, Fukuoka Tokushukai Hospital
4-5 Sukukita, Kasuga, Fukuoka, 816-0864 JAPAN

Accepted
July 23, 2008

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