Cholangiocellular Carcinoma Associated with Wilson's Disease

Tomoaki Saito, Manabu Watanabe, Hidenori Tanaka, Koji Asai, Akihiro Osawa, Hiroshi Matsukiyo, Shinya Kusachi, Jiro Nagao, Kei Takahashi¹⁾ and Norikazu Shimizu²⁾

The Third Department of Surgery, Department of Pathology¹⁾ and Second Department of Pediatrics²⁾, Toho University Ohashi Medical Center

We report a rare case of cholangiocellular carcinoma associated with Wilson's disease (WD). A 39-year-old man diagnosed with WD at age 11 and administrated a copper chelating agent was hospitalized for further examination and treatment at age 39 after a tumorous lesion 40 mm in diameter was found. A series of imaging tests and percutaneous needle biopsy indicated well-differentiated adenocarcinoma. Following percutaneous transhepatic portal embolization, he underwent right hepatic lobectomy and lymph node dissection. The definitive histopathological diagnosis was moderately-differentiated cholangiocellur carcinoma with tumor formation.

Key words
Wilson's disease, hepatocellular carcinoma, cholangiocellular carcinoma

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Tomoaki Saito The Third Department of Surgery, Toho University School of Medicine
2-17-6 Ohashi, Meguro-ku, 153-8515 JAPAN

Accepted
February 18, 2009

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