A Case of Gastric Cancer with Autosomal Dominant Polycystic Kidney Disease

Hidetaka Yamanaka, Haruru Asamoto, Takahiko Ishizaka, Satoru Kawai, Hiroyuki Matsunaga, Yasushi Kitoh, Satoaki Kamiya and Yasutaka Matsuzaki

Department of Surgery, Tsushima City Hospital

A 50-year-old man referred for abdominal pain had taken hypertension and general eczema medication from age 48 originated for autosomal dominant polycystic kidney disease (ADPKD) diagnosed when he was 35 years old. His father had died of "chronic renal failure" for which no details were known. Based on a diagnosis of scirrhous gastric cancer indicated by upper gastrointestinal series and fiberscopy, he underwent total gastrectomy. The definitive diagnosis was poorly differentiated adenocarcinoma including signet ring cell carcinoma and peritonitis carcinomatosa. He was discharged on postoperative day12 and remains alive 1 year and 3 months undergoing anticancer-agent chemotherapy. The relationship between ADPKD and neoplasm was reported to account for polycystin-1 and polycystin-2 produced from a pathogenesis gene of ADPKD, which is caused by genes mutation in vitro. This is clinically controversial however, and was not reported about gastric cancer. We studied autopsy cases in Japan form 2002 to 2006, which showed no association on sideration about gastric cancer in ADPKD and also showed many nondifferentiated type gastric cancer, it is not ascertained.

Key words
autosomal dominant polycystic kidney disease (ADPKD), gastric cancer, PKDgene

Reprint requests
Hidetaka Yamanaka Department of Surgery, Tsushima City Hospital
3-73 Tachibana-cho, Tsushima, 496-8537 JAPAN

Accepted
October 28, 2009

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