A Successful Treatment for Adenocarcinoma arising in Meckel's Diverticulum combined with Krukenberg's Tumor; Report of a Case

Shun-ichi Ishigami, Takefumi Yazawa²⁾, Hideaki Ooe, Kazuhiko Kitaguchi, Katsuaki Ura, Kaoru Taira, Akira Yoshikawa, Jun Tamura, Nobuo Baba and Tomoyuki Shirase¹⁾

Department of Surgery and Department of Pathology¹⁾, Otsu Red Cross Hospital
Shigaraki Central Hospital²⁾

A sixty nine-year-old woman who had undergone oophorectomy for a right ovarian tumor in November 2004 underwent resection for a tumor 2 cm in diameter arising in Meckel's diverticulum in the ileum 70 cm above the ileocecal valve. Histopathologically, both tumors were diagnosed as moderately differentiated adenocarcinoma. Immunohistochemistry results were as follows: cytokeratin (CK) 7 (-), 20 (+), mucin core protein (MUC) 1 (+), MUC 2 (-), and MUC 5AC (+). CK profiles and MUC expression indicated that the Meckel's diverticulum tumor may be adenocarcinoma arising from ectopic epithelium and that the ovarian tumor was metastatic. After systemic chemotherapy with TS-1 and cisplatin (CDDP), she remains alive for 4 years and 3 months since initial surgery. Of the 46 cases of adenocarcinoma arising in Meckel's diverticulum and reported worldwide since 1950, this is, to our knowledge, the first combined with Krukenberg's tumor. We suspect that this case may have been "ectopic gastric cancer" and successful treatment may lead to a comparatively long survival.

Key words
Meckel's diverticulum, Krukenberg's tumor, chemotherapy

Reprint requests
Shun-ichi Ishigami Department of Surgery, Otsu Red Cross Hospital
1-1-35 Nagara, Otsu, 520-8511 JAPAN

Accepted
September 16, 2009

To read the PDF file you will need Abobe Reader installed on your computer.