A Case of Hereditary Gastric Cancer with Diffuse Multiple Lesions in the Stomach

Keishi Sugimachi, Hidefumi Higashi, Dai Kitagawa, Junko Tanaka, Yosuke Nagayoshi, Atsushi Mizuta, Ichiro Makino, Masakazu Aso and Tatsuro Shimokama*

Department of Surgery and Department of Pathology*, Nippon Steel Yawata Memorial Hospital

A 32-year-old woman seen for epigastralgia and diagnosed with early gastric cancer of the upper stomach was found histologically to have signet-ring cell carcinoma. Her grandfather, mother, brother, and uncle had died of diffuse gastric cancer between the ages of 26 and 32. Following total gastrectomy with Roux-en-Y esophagojejunostomy, pathological examination showed 38 signet-ring cell carcinoma lesions restricted to the mucosa of the stomach. This case was considered juvenile familial gastric cancer, with a clinical character very similar to hereditary diffuse gastric cancer due to E-cadherin (CDH-1) gene mutation.

Key words
juvenile gastric cancer, familial gastric cancer, E-cadherin

Reprint requests
Keishi Sugimachi Department of Surgery, Nippon Steel Yawata Memorial Hospital
1-1-1 Harunomachi, Yahatahigashi-ku, Kitakyushu, 805-8508 JAPAN

Accepted
January 27, 2010

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