A Case of Solitary Fibrous Tumor of the Liver with Hypoglycemia

Masaru Tsuchiya, Yuichiro Otsuka, Akira Tamura, Kouji Kuboki¹⁾, Tsutomu Hatori²⁾ and Hironori Kaneko

Division of General and Gastroenterological Surgery, Department of Surgery (Omori), Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine (Omori) ¹⁾ and Department of Surgical Pathology²⁾, School of Medicine, Faculty of Medicine Toho University

We report a very rare case of solitary fibrous tumor (SFT) of the liver. A 52-year-old woman admitted for consciousness disturbance had a tumor palpated in the low abdomen. Blood glucose was 22 mg/dl. Hypoglycemia was improved by glucose DIV. Tumor markers were normal. Blood insulin and C-peptide were low, but IGF-I and IGF-II were normal in endocrinological examination. Abdominal computed tomography showed an idiopathic tumor 20 cm in diameter in the abdominal cavity drooping over the pelvis from the left lateral liver, and necessitating partial hepatectomy with tumorectomy. The resected tumor 25.0×22.5×6.4 cm, 3 kg weighted. Histological examination showed SFT of the liver with tumor cells positive for vimentin and CD34. Immunohistologically, C-kit was negative. The postoperative course was uneventful and hypoglycemic symptoms immediately disappeared. The woman remains well and without recurrence 3 years after surgery. Most hepatic SFT is benign but may have malignant histological features and recur locally or metastasize-a fact that diagnosticians should be aware of.

Key words
solitary fibrous tumor, liver tumor, hypoglycemia

Reprint requests
Masaru Tsuchiya Department of Gastroenterological Surgery, Toho University Omori Medical Center
6-11-1 Omori-Nishi, Ota-ku, 143-8541 Japan

Accepted
January 27, 2010

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