Influence of Intrapotal Infusion with Lipiodol and Aclarubicin on Regenerating Liver in Rats

Hiroyuki Suzuki, Masaru Miyazaki, Toshio Isono, Katsuji Okui

First Department of Surgery, Chiba University, School of Medicine

The effect of intraportal infusion with acarubicin (ACR) and lipiodol (LP) on normal liver and regenerating liver was studied in rats. In normal liver intraportal infusion of ACR and LP had no effect on the serum transaminase level or the aminopyrine breath test (ABT). In regenerating liver, hepatic DNA synthesis was significantly inhibited 24 hours after two-thirds hepatectomy by intraportal infusion with ACR and LP, but the peak of hepatic DNA syntheis was delayed at 36 to 48 hours after hepatectomy. The decrease of the ABT and the increase in serum transaminase level were more marked in regenerating liver than in normal liver, but there were no intragroup differences. The ABT values depressed after hepatectomy had returned to normal 3 weeks after the operation. No deaths occured until 21 days after infusion and hepatectomy. These data show that intraportal infusion with ACR and LP caused no obvious damage to normal liver. Although the infusion in regenerating liver induced slight suppression and delay in DNA synthesis, the hepatic functional mass depressed after hepatectomy soon recovered to the normal level. In conclusion this study suggests that intraportal infusion with ACR and LP is a safe therapeutic modality even after hepatectomy.

Key words
hepatectomy, intraportal chemotherapy, lipiodol, liver regeneration

Reprint requests
Hiroyuki Suzuki First Department of Surgery, School of Medicine, Chiba University
1-8-1 Inohana, Chiba, 280 JAPAN

Accepted
October 11, 1990

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