An Experimental Study on Gastric Secretion Following Proximal Massive Small Bowel Resection

Masamitsu Harada, Daisuke Wada, Hideki Kawasaki, Nobuhiko Komi

First Department of Surgery, School of Medicine, The University of Tokushima

The effect of two-thirds proximal small bowel resection (2/3 PSBR) on gastric secretion, plasma gastrin and histamine levels in the right gastroepiploic vein (RGEV), and antral G cell and parietal cell populations were studied by using a canine experimental model. Three or 4 weeks after 2/3 PSBR, the rates of increase in basal acid output (BAO), maximal acid output (MAO) and the parietal cell population were 48.5%, 282% and 16.4% and the rates of decrease in plasma gastrin and histamine levels and the antral G cell population were 57.8%, 32.2%% and 10.9%, respectively. Eleven or 12 weeks after 2/3 PSBR, BAO had decreased to almost the preoperative level but the MAO was still high. Plasma gastrin and histamine levels tended to increase to almost the preoperative levels and the parietal cell population had slightly decreased, but the antral G cell population had increased. These results suggest that the increase in the parietal cell population or the parietal cell response is directly associated with postoperative hyperacidity and that the change in plasma gastrin and histamine levels in the RGEV is influenced by the acid secretion feedback mechanism.

Key words
massive small bowel resection, plasma gastrin, plasma histamine, G cell population, parietal cell population

Reprint requests
Masamitsu Harada First Department of Surgery, School of Medicine, The University of Tokushima
3-18-15 Kuramoto-cho, Tokushima, 770 JAPAN

Accepted
December 10, 1991

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