A Case of Gastric Cancer in Patient with Dyskeratosis Congenita

Kotaro Matsushita, Shinya Yamamoto, Setsuo Okada, Atsushi Shinohara, Satoshi Tanaka

First Department of Surgery, Kagawa Medical School

A case of gastric cancer in a 37-year-old man with dyskeratosis congenita is reported. His chief complaints were anorexia and weight loss, and gastric cancer was detected by an upper gastrointestinal series and endoscopic examination. Laparotomy disclosed cancer occupying the body and antrum of the stomach and its liver infiltration and peritoneal dissemination. No leukoplakia was found in the resected gastric mucosa. Histological examination revealed adenocarcinoma. The patient died of a massive gastrointestinal hemorrhage following disseminated intravascular coagulation 90 days after surgery. We place particular emphasis on the development of adeno-carcinoma of the gastrointestinal tract at an early age in patients with this disease, in addition to carcinoma arising from leukoplakia, based on our experience and a few reports in the literature.

Key words
dyskeratosis congenita, ideopathic portal hypertension, gastric cancer

Reprint requests
Kotaro Matsushita First Department of Surgery, Kagawa Medical School
1750-1 Ikenobe Miki-cho, Kita-gun, Kagawa, 761-07 JAPAN

Accepted
December 10, 1991

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