Clinicopathological and Nuclear DNA Analyses of Gastric Leiomyomatous Tumors

Masato Funasaka, Takeshi Nakamura, Yoshiki Tabuchi*, Yasuyuki Tada, Toru Morishita, Shiro Kawamura, Michio Kato, Yoichi Saito

First Department of Surgery, Kobe University School of Medicine and School of Allied Medical Sciences*, Kobe University

Ten leiomyosarcomas and 8 leiomyomas of the stomach were examined clinicopathologically, and the nuclear DNA patterns in 6 of the myosarcomas and 5 of the myomas were analyzed by flow cytometry (FCM) using paraffin-embedded tissues. The average size (103 cm) of the myosarcomas was significantly (p<0.01) larger than that (4.9 cm) of the myomas, and there was a negative correlation (Y=23.3-0.35X, r=-0.907, p<0.01) between tumor size and survival period among 5 patients died of the disease. The average number of mitoses was also significantly (p<0.05) higher in the myosarcomas (49.3/100 HPF) than the myomas (2.6/100 HPF). All the myomas and 1 of the myosarcomas showed a diploid pattern, and none of these patients died of the disease. Five myosarcomas showed an aneuploid pattern (mean DI=1.72), and 3 of patients died of the disease. These data indicate that tumor size, number of mitoses and analysis of DNA patterns by FCM are valuable for determining the grade of malignancy and therapeutic method, and predicting prognosis for patients with leiomyomatous tumors of the stomach.

Key words
gastric leiomyomatous tumor, mitosis, cellularity, nuclear DNA ploidy pattern, flow cytometory

Reprint requests
Masato Funasaka First Department of Surgery, Kobe University School of Medicine
7-5-2 Kusunoki-cho Chuo-ku, Kobe, 650 JAPAN

Accepted
February 12, 1992

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